Resolved: Economic sanctions ought not be used to achieve foreign policy objectives.The "ought" ostensibly makes this a matter of morality, which leads to the Affirmative's main question: why might economic sanctions be immoral? There are many reasons; perhaps the most common would be because they harm innocents, concomitant with the argument that they don't actually work, or, worse, are counterproductive, increasing the power of those they're meant to weaken. (Cuba and North Korea spring to mind.)
In essence, this is at least a two-layered debate, since the Negative will likely have to argue that not only are sanctions morally good, but good for something.
A deeper question concerns the role of morality in foreign policy. Idealists will value human rights (and any binding obligations to upholding them), while realists will call for prudence. Moral cosmopolitanism might come into play, as might international law and the role / effectiveness of the United Nations in enforcing sanctions.
Links and Further Analysis
As a kick-starter, an oldie but goodie from Franklin Foer, distinguishing trade from economic sanctions, determining whether they work (the upshot: hard to say), and summing up the costs.
Iraq and the "terrible price" of sanctions.
Looking at some empirical research to answer the question, Do sanctions even work?
Can the Neg justify the use of sanctions even if they largely aren't successful? And what's the cost/benefit analysis of the alternatives? A consequentialist take on the resolution.
Added 12/13: A nascent list of value/criterion pairs.
Added 12/15: Some alternatives to economic sanctions are considered.
Added 1/3: The Negative's use of "targeted sanctions" is considered.
Added 1/3: I answer a bushel of questions about the resolution.
Added 1/10: Some strategic considerations about the definition of economic sanctions.
Added 1/24: A critical view of sanctions, slanted toward the Aff.
Added 2/8: Some economic analysis, plus an alternative approach for the Aff.
As always, more--much more!--analysis and links will follow. And, of course, your questions and comments are what really make this website worthwhile.